For a long time, I've been somewhat fascinated by depression. I've had friends who suffered from it. I studied psychology in college, and depression was a part of those studies. I've read personal essays and fiction describing the abyss and clustercuss that is a depressive episode. But none of these experiences have made the experience as clear as Zoe's Depression Quest
(well, Zoe Quinn and Patrick Lindsey). If you choose to isolate yourself and give in to feeling crummy, your depression gets worse. These negative feedback loops are the things that feed depression. But you can't "just do" things or snap out of it--depending on your depression level, certain options will be unavailable.
Playing this game fills me with compassion for those who suffer from depression. It also helps me recognize my own "depressive"* thoughts--like when it seems like everyone is doing cooler things than me, or when I feel useless, or when I don't feel like talking to anyone I haven't known for more than two years. I think everyone should play this game--it will make you more compassionate and understanding if you haven't suffered from depression, and it might help you feel like you're not alone if you have.
*I don't have clinical depression. But we all get down sometimes.